Lidy M Pelsser MSc, Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trialThe Lancet, Volume 377, Issue 9764, Pages 494 - 503, 5 February 2011
Effects of food on physical and sleep complaints in children with ADHD: a randomised controlled pilot study.
Pelsser LM, Frankena K, Buitelaar JK, Rommelse NN.
Eur J Pediatr. 2010 Sep;169(9):1129-38.
ADHD as a (non) allergic hypersensitivity disorder: a hypothesis.
Pelsser LM, Buitelaar JK, Savelkoul HF.
Pediatr Allergy Immunol. 2009 Mar;20(2):107-12.
Department of Paediatrics, University of Rome La Sapienza, Italy.
The etiopathogenesis of infantile autism is still unknown. Recently some authors have suggested that food peptides might be able to determine toxic effects at the level of the central nervous system by interacting with neurotransmitters. In fact a worsening of neurological symptoms has been reported in autistic patients after the consumption of milk and wheat. The aim of the present study has been to verify the efficacy of a cow's milk free diet (or other foods which gave a positive result after a skin test) in 36 autistic patients. We also looked for immunological signs of food allergy in autistic patients on a free choice diet. We noticed a marked improvement in the behavioural symptoms of patients after a period of 8 weeks on an elimination diet and we found high levels of IgA antigen specific antibodies for casein, lactalbumin and beta-lactoglobulin and IgG and IgM for casein. The levels of these antibodies were significantly higher than those of a control group which consisted of 20 healthy children. Our results lead us to hypothesise a relationship between food allergy and infantile autism as has already been suggested for other disturbances of the central nervous system.