Melatonin Supplementation in the Treatment of Insomnia and ADHD in Children


“Melatonin Treatment for Insomnia in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder (January),” Bendz LM, Scates AC, Ann Pharmacother, 2009 Dec 22; [Epub ahead of print]. (Address: Drug Information Specialty Resident, Department of Pharmacy, Duke University Hospital, Durham, NC, USA).

In this article, the authors reviewed the efficacy and safety of melatonin in the treatment of insomnia in pediatric patients with attention-deficit/hyperactivity disorder (ADHD). Literature was accessed through MEDLINE, EMBASE and Scopus. Results from 5 randomized trials, 1 safety study, 1 long-term follow-up study, 1 retrospective analysis, 2 meta-analyses, 9 review articles and 1 letter were summarized and found to show that melatonin is a well-tolerated and efficacious treatment option for children with chronic sleep-onset insomnia and ADHD. Studies included children 6-14 years old and melatonin doses ranged from 3 to 6 mg administered within a few hours of a scheduled bedtime.