Individuals who have psychological disorders and also high-histamine levels may be suffering from a metabolic imbalance called Histadelia.  Due to an inefficient or defective biochemical process called methylation, these individuals overproduce and retain excess levels of histamine.  Methylation is a biochemical process responsible for DNA synthesis, neurotransmitter production, detoxification, mineral metabolism, nerve transmission and cell signaling.  When methylation is impaired, production of neurotransmitters is also impaired and substances such as histamine are not bio-transformed and eliminated.

Histamine is a substance in the body that has wide ranging effects.  It is a major chemical messenger involved in the allergic cascade of cell signaling.  There are receptors for histamine in the brain, stomach, skin, lungs, mucus membranes and blood vessels.  When histamine is high for long periods of time, the nervous system can be affected.  Any source of inflammation, from chronic disease, inhalant allergens to food allergies, can affect mood, behavior and brain function of patients with histadelia.

Many patients with obsessive-compulsive tendencies, oppositional-defiant behaviors, attention deficit disorders or seasonal depression are under-methylating, which is associated with low serotonin levels.  Often these patients concurrently suffer from inhalant allergies,  headaches, eczema, asthma, and multiple food allergies. Patients with histadelia tend to be deficient in calcium, magnesium, methionine, and vitamin B-6. People with histadelia may have a positive effect from SSRIs and other serotonin-enhancing medications (Paxil, Zoloft, Prozac, Celexa, Effexor, etc.) because methylation is a step in the manufacture of mood stabilizing neurotransmitters.  Unfortunately, histadelics often have negative physical side effects with these medications due to their chemical sensitivity and volatility.

Biomedical treatment revolves around nutrient replacement of calcium, essential fatty acids and methionine. Certain forms of buffered vitamin C can help by providing calcium and ascorbic acid.  IV Phosphatidylcholine along with IV B complex vitamins are also extremely effective. Three to six months of nutrient therapy are usually needed to correct this chemical imbalance. As in most biochemical therapies, the symptoms usually return if treatment is stopped.