Pyroluria
Pyroluria is a condition that was originally discovered because of its link with Schizophrenia. Recently, however, studies show that pyroluria is also associated with disorders such as depression, autism, ADHD and alcoholism.
What exactly is Pyroluria?
Pyroluria anxiety/depression results from a genetic problem with hemoglobin metabolism that creates a biproduct that binds irreversible with Vitamin B-6. This biproduct is called kryptopyrrole or mauve factor. This results in a chronic deficiency of both vitamin B6 and zinc. Primary symptoms include mood swings, rage, stress intolerance, and anxiety. Other common symptoms include: fatigue, poor dream recall, forgetfulness, tendency for addictive behavior, and a poor morning appetite. Mental symptoms are aggravated when under stress. Not all symptoms need to be present to benefit from treatment. If positive for pyroluria one must avoid excess fish oil, copper, and red and yellow food dyes.
How do I know if I have Pyroluria?
The definitive lab is a urine test that measures levels of kryptopyrrole. Any person struggling with addiction or with the above symptoms should be tested. This test is very inexpensive and is available from our office.
How do I treat Pyroluria?
Treatment for pyroluria is supplementation of high doses of vitamin B6 and zinc. The results will be evident in 2 days to 2 weeks (depending on the severity of pyroluria). Total reversal of symptoms may take three to four months. This is a genetic condition, therefore, if supplementation is stopped, the symptoms return within one to two weeks. Adverse effects have been seen in some patients in regards to high doses of zinc and B-6, therefore, this level of supplementation should only be done under the supervision of a qualified health care provider.
Symptoms of Pyroluria:
| Tendency to sunburn |
Prone to side stitches |
| Weak appetite in the morning |
Unexplained nausea |
| Hypoglycemia |
Motion sickness |
| Panic attacks |
Depression |
| Anxiety, sometimes severe |
Bipolar disorder |
| Schizophrenia |
Allergies |
| Alcohol problems |
Forgets dreams |
| Easily fatigued |
Emotional instability |
| Antisocial |
White spots on fingernails |
| Joint pain |
Poor reaction to stress |
| Famous for their temper |
Mood swings |
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Sensitivity to light
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